TY - JOUR
KW - ASTHMA
KW - CHILD HEALTH
KW - allergy
KW - indoor allergens
KW - pollutants
KW - environmental intervention
KW - clinical trials
AU - Diane R. Gold
AU - Gary Adamkiewicz
AU - Syed Hasan Arshad
AU - Juan C. Celedón
AU - Martin D. Chapman
AU - Ginger L. Chew
AU - Donald N. Cook
AU - Adnan Custovic
AU - Ulrike Gehring
AU - James E. Gern
AU - Christine C. Johnson
AU - Suzanne Kennedy
AU - Petros Koutrakis
AU - Brian Leaderer
AU - Herman Mitchell
AU - Augusto A. Litonjua
AU - Geoffrey A. Mueller
AU - George T. O'Connor
AU - Dennis Ownby
AU - Wanda Phipatanakul
AU - Victoria Persky
AU - Matthew S. Perzanowski
AU - Clare D. Ramsey
AU - Päivi M. Salo
AU - Julie M. Schwaninger
AU - Joanne E. Sordillo
AU - Avrum Spira
AU - Shakira F. Suglia
AU - Alkis Togias
AU - Darryl C. Zeldin
AU - Elizabeth C. Matsui
AB - Environmental exposures have been recognized as critical in the initiation and exacerbation of asthma, one of the most common chronic childhood diseases. The National Institute of Allergy and Infectious Diseases; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; and Merck Childhood Asthma Network sponsored a joint workshop to discuss the current state of science with respect to the indoor environment and its effects on the development and morbidity of childhood asthma. The workshop included US and international experts with backgrounds in allergy/allergens, immunology, asthma, environmental health, environmental exposures and pollutants, epidemiology, public health, and bioinformatics. Workshop participants provided new insights into the biologic properties of indoor exposures, indoor exposure assessment, and exposure reduction techniques. This informed a primary focus of the workshop: to critically review trials and research relevant to the prevention or control of asthma through environmental intervention. The participants identified important limitations and gaps in scientific methodologies and knowledge and proposed and prioritized areas for future research. The group reviewed socioeconomic and structural challenges to changing environmental exposure and offered recommendations for creative study design to overcome these challenges in trials to improve asthma management. The recommendations of this workshop can serve as guidance for future research in the study of the indoor environment and on environmental interventions as they pertain to the prevention and management of asthma and airway allergies.
BT - Journal of Allergy and Clinical Immunology
DO - 10.1016/j.jaci.2017.04.024
N2 - Environmental exposures have been recognized as critical in the initiation and exacerbation of asthma, one of the most common chronic childhood diseases. The National Institute of Allergy and Infectious Diseases; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; and Merck Childhood Asthma Network sponsored a joint workshop to discuss the current state of science with respect to the indoor environment and its effects on the development and morbidity of childhood asthma. The workshop included US and international experts with backgrounds in allergy/allergens, immunology, asthma, environmental health, environmental exposures and pollutants, epidemiology, public health, and bioinformatics. Workshop participants provided new insights into the biologic properties of indoor exposures, indoor exposure assessment, and exposure reduction techniques. This informed a primary focus of the workshop: to critically review trials and research relevant to the prevention or control of asthma through environmental intervention. The participants identified important limitations and gaps in scientific methodologies and knowledge and proposed and prioritized areas for future research. The group reviewed socioeconomic and structural challenges to changing environmental exposure and offered recommendations for creative study design to overcome these challenges in trials to improve asthma management. The recommendations of this workshop can serve as guidance for future research in the study of the indoor environment and on environmental interventions as they pertain to the prevention and management of asthma and airway allergies.
PY - 2017
SP - 933 
EP -  949
T2 - Journal of Allergy and Clinical Immunology
TI - NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma—implications for home environmental intervention in asthma prevention and management
UR - http://www.sciencedirect.com/science/article/pii/S0091674917307480
VL - 140
SN - 0091-6749
ER -